Drug intelligence / Profile preview

meningococcal (ACYW) diphtheria toxoid conjugate vaccine

Development stage
Approved
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Meningococcal (ACYW) diphtheria toxoid conjugate vaccine is a quadrivalent vaccine designed to protect against invasive disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135. It is a conjugate vaccine in which meningococcal polysaccharides or oligosaccharides from these serogroups are covalently linked to diphtheria toxoid or a specific diphtheria protein (e.g., CRM197), enhancing immunogenicity especially in young children. The vaccine induces protective antibody responses by stimulating T-cell dependent immunity. It does not protect against serogroup B Neisseria meningitidis. The primary indication is the prevention of invasive meningococcal disease, including meningitis and meningococcemia, in individuals at risk, particularly those aged 2 months through 55 years[1][3][5][6].

Brand names
MenveoMenactraMenQuadfi
Other names
meningococcal ACYW conjugate vaccinequadrivalent meningococcal conjugate vaccinemeningococcal (Groups A, C, Y, and W-135) oligosaccharide diphtheria conjugate vaccinemeningococcal diphtheria conjugate vaccinemeningococcal polysaccharide diphtheria conjugate vaccine
02

Targets

Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)

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