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meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine + diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed

Development stage
Unknown
Lead developer
Sanofi Pasteur
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Menactra + Daptacel refers to the concomitant administration of two distinct vaccines developed by Sanofi Pasteur: Menactra, a quadrivalent meningococcal conjugate vaccine, and Daptacel, a diphtheria, tetanus, and acellular pertussis (DTaP) vaccine. Menactra is indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135 in individuals aged 9 months through 55 years. Daptacel is indicated for active immunization against diphtheria, tetanus, and pertussis as a five-dose series in children 6 weeks through 6 years of age. Clinical studies have evaluated the safety and immunogenicity of administering these two vaccines at the same visit but at different injection sites, confirming that the immune response to each vaccine is maintained without significant interference. This combination is commonly used in pediatric and adolescent immunization schedules to reduce the number of healthcare visits.

Other names
MCV4 + DTaP
02

Targets

FHA (Filamentous hemagglutinin)FIM2/FIM3 (Fimbriae types 2 and 3)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)PRN (Pertactin)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)TT (Tetanus toxoid)

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