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Meningococcal ABCWY
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The meningococcal ABCWY (MenABCWY) vaccine is a pentavalent combination vaccine designed to protect against invasive disease caused by *Neisseria meningitidis* serogroups A, B, C, W, and Y. It combines the antigenic components of two existing vaccines—Bexsero (for group B) and Menveo (for groups A, C, W-135, and Y)—to provide broad coverage in a single immunization regimen. The mechanism of action involves stimulating the immune system to produce bactericidal antibodies targeting the capsular polysaccharides of serogroups A, C, W, Y as well as factor H binding protein (fHbp) from group B strains. These antibodies mediate complement-dependent killing of *N. meningitidis* bacteria[6][8]. The primary indication is prevention of invasive meningococcal disease in adolescents and young adults.
- Brand names
- PenbrayaPenmenvy
- Other names
- 5-in-1 meningococcal vaccinepentavalent meningococcal vaccine
02
Targets
PorA (Major outer membrane protein PorA)Neisseria meningitidis group C capsular polysaccharideNHBA (Neisserial heparin-binding antigen)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)NadA (Neisserial adhesin A)MenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)fHbp (Factor H-binding protein)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)CFH (Complement factor H)
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