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meningococcal ABCWY vaccine
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The meningococcal ABCWY vaccine (specifically the candidate developed by GSK, often identified as GSK3536852A) is a pentavalent combination vaccine designed to provide broad protection against invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, B, C, W, and Y. It is formulated by combining the components of two existing GSK vaccines: Bexsero (a multicomponent serogroup B vaccine) and Menveo (a quadrivalent A, C, W-135, and Y conjugate vaccine). The vaccine aims to simplify immunization schedules by covering the five most prevalent serogroups in a single product, particularly for adolescents and infants. It utilizes a combination of recombinant proteins, outer membrane vesicles (OMV), and polysaccharide-protein conjugates to elicit a robust bactericidal antibody response against the targeted serogroups.
- Brand names
- Penbraya
- Other names
- combined meningococcal ABCWY vaccinepentavalent meningococcal vaccineGSK MenABCWY
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)NHBA (Neisserial heparin-binding antigen)Neisseria meningitidis group C capsular polysaccharideNadA (Neisserial adhesin A)MenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)fHbp (Factor H-binding protein)
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