Drug intelligence / Profile preview

meningococcal ABCYW vaccine (Sanofi)

Development stage
Unknown
Lead developer
Sanofi Pasteur
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The meningococcal ABCYW vaccine (specifically Sanofi's SP0230) is a pentavalent vaccine candidate designed to provide broad protection against invasive meningococcal disease (IMD) caused by *Neisseria meningitidis* serogroups A, B, C, W, and Y. Developed by Sanofi Pasteur, the vaccine combines the capsular polysaccharide conjugates from a quadrivalent MenACWY vaccine (such as MenQuadfi) with recombinant protein antigens targeting serogroup B (such as factor H binding protein). By covering all five major pathogenic serogroups in a single immunization series, it aims to simplify vaccination schedules and increase coverage against MenB, which is often administered separately from the quadrivalent conjugate vaccines. The vaccine is currently in Phase 2 clinical development for use in infants, toddlers, and children.

Other names
Pentavalent meningococcal vaccineMenABCWY vaccineMenPenta
02

Targets

fHbp (Factor H-binding protein)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)TT (Tetanus toxoid)

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