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meningococcal B vaccine + meningococcal ACWY conjugate vaccine + paracetamol
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules, Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Oral
01
Overview
This combination refers to the clinical co-administration of vaccines targeting five major serogroups of *Neisseria meningitidis* (A, B, C, W, and Y) along with paracetamol (acetaminophen). The meningococcal B vaccine (e.g., Bexsero) is a multicomponent vaccine containing recombinant proteins and outer membrane vesicles, while the meningococcal ACWY vaccine is a conjugate vaccine where capsular polysaccharides are linked to a carrier protein (such as CRM197 or tetanus toxoid). Paracetamol is administered prophylactically or therapeutically to manage the high rate of fever (pyrexia) specifically associated with the MenB vaccine, particularly in infants. This regimen is standard in several national immunization programs to provide broad protection against invasive meningococcal disease while mitigating common systemic adverse reactions.
- Other names
- MenB + MenACWY + paracetamolBexsero + Menveo + paracetamolTrumenba + Nimenrix + paracetamol
02
Targets
PorANHBA (Neisserial heparin-binding antigen)MenACWY (Capsular polysaccharides of Neisseria meningitidis serogroups A, C, W, and Y)NadA (Neisserial adhesin A)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)fHbp (Factor H-binding protein)
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