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meningococcal group A, C, W, and Y tetanus toxoid conjugate vaccine
- Development stage
- Phase 3
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
MenACWY-TT is a quadrivalent conjugate vaccine designed to protect against invasive disease caused by *Neisseria meningitidis* serogroups A, C, W, and Y. The vaccine contains capsular polysaccharides from these four serogroups conjugated to tetanus toxoid as a carrier protein. It induces an immune response that generates protective antibodies against the targeted serogroups. MenACWY-TT has demonstrated high immunogenicity and an acceptable safety profile in infants (as young as 6 weeks), children, adolescents, and adults. It can be co-administered with other routine vaccines without compromising efficacy or safety. Originally developed by GSK Biologicals (now GSK), it was later acquired by Pfizer[1][5]. The primary indication is prevention of invasive meningococcal disease[1][5].
- Brand names
- NimenrixMenQuadfi
- Other names
- meningococcal quadrivalent tetanus toxoid conjugate vaccine
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)TT (Tetanus toxoid)
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