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meningococcal group A, C, W-135 and Y conjugate vaccine (Sanofi)
- Development stage
- Approved
- Lead developer
- Sanofi
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A quadrivalent meningococcal conjugate vaccine (MenACWY) is a biologic vaccine designed to provide active immunization against invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, W-135, and Y. Unlike older polysaccharide vaccines, the conjugate formulation chemically links the capsular polysaccharides of the bacteria to a carrier protein (such as CRM197, tetanus toxoid, or diphtheria toxoid). This conjugation converts the T-cell independent polysaccharide antigens into T-cell dependent antigens, inducing immunological memory, higher antibody titers, and longer-lasting protection across all age groups, including infants. It also has the potential to reduce nasopharyngeal carriage of the bacteria, thereby contributing to herd protection.
- Brand names
- MenveoMenactraNimenrixMenQuadfi
- Other names
- quadrivalent ACWY meningococcal conjugate vaccineMenACWY conjugate vaccinequadrivalent meningococcal conjugate vaccine
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)TCR-CRM197/DT (T-cell receptor (TCR) recognizing CRM197 or diphtheria toxoid peptides presented on MHC class II)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)BCR (Immunoglobulin G B Cell Receptor)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)
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