Drug intelligence / Profile preview

meningococcal group B recombinant lipoprotein 2086 vaccine

Development stage
Approved
Lead developer
Pfizer
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

A recombinant protein vaccine developed for the prevention of invasive disease caused by *Neisseria meningitidis* serogroup B. It contains two recombinant lipidated factor H binding proteins (fHBP) from divergent serogroup B strains. Its mechanism relies on eliciting immune responses that generate bactericidal antibodies against meningococcal serogroup B, preventing severe conditions like meningitis and sepsis. The vaccine is indicated primarily for adolescents and young adults at high risk of exposure or during outbreaks. It is not expected to protect against serogroups other than B.

Brand names
Trumenba
Other names
meningococcal group B rLP2086 vaccinemeningococcal group B recombinant lipoprotein 2086 vaccinerLP2086 vaccinerLP-2086 vaccinerLP 2086 vaccinebivalent recombinant LP2086Trumenba
02

Targets

CFH (Complement factor H)Factor H-binding protein (fHbp) subfamily BFactor H-binding protein subfamily A

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