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meningococcal group C polysaccharide-tetanus toxoid conjugate vaccine + pneumococcal 7-valent CRM197-conjugate vaccine

Development stage
Unknown
Lead developer
Pfizer
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This is a combination of two vaccines used to protect against invasive bacterial diseases in children and at-risk populations. The first component is the meningococcal group C polysaccharide-tetanus toxoid conjugate vaccine (MenC-TT), which consists of the capsular polysaccharide from *Neisseria meningitidis* serogroup C covalently linked to tetanus toxoid as a carrier protein. This conjugation enhances immunogenicity by inducing T-cell dependent immune responses and immune memory even in infants[1]. The second component is the pneumococcal 7-valent CRM197-conjugate vaccine (PCV7), which contains purified capsular polysaccharides from seven *Streptococcus pneumoniae* serotypes individually conjugated to CRM197, a non-toxic mutant of diphtheria toxin. Both vaccines work by stimulating the immune system to produce protective antibodies against their respective pathogens[1][4][5]. These vaccines are highly effective in preventing serious diseases such as bacterial meningitis and sepsis caused by these bacteria.

Brand names
MenjugateNeisVac-CPrevenar
02

Targets

CPS23F (Streptococcus pneumoniae capsular polysaccharide serotype 23F)CPS4 (Streptococcus pneumoniae capsular polysaccharide serotype 4)Neisseria meningitidis group C capsular polysaccharideCPS14 (Streptococcus pneumoniae capsular polysaccharide serotype 14)CPS19F (Streptococcus pneumoniae capsular polysaccharide serotype 19F)CPS 18C (Streptococcus pneumoniae capsular polysaccharide serotype 18C)Streptococcus pneumoniae capsular polysaccharide serotype 9V (PnPS 9V)6B CPS (Streptococcus pneumoniae serotype 6B capsular polysaccharide)TT (Tetanus toxoid)

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