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meningococcal groups a, c, y and w135 polysaccharide conjugate vaccine
- Development stage
- Phase 3
- Lead developer
- Yuxi Watson Biotechnology
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A quadrivalent conjugate vaccine designed to prevent invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W-135. Developed by Yuxi Watson Biotechnology (a subsidiary of Walvax Biotechnology), it consists of capsular polysaccharides from each of the four serogroups individually conjugated to a tetanus toxoid carrier protein. This conjugation converts the T-cell independent polysaccharide antigens into T-cell dependent antigens, inducing a more robust immune response and immunological memory, particularly in infants and young children. It was approved in China in 2022 for use in children from 3 months to 3 years of age.
- Brand names
- MennoYuxi
- Other names
- MCV4-TTMCV-4-TTMCV 4-TTQuadrivalent Meningococcal Conjugate Vaccine
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)TT (Tetanus toxoid)
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