Drug intelligence / Profile preview

meningococcal groups A and C and haemophilus b conjugate vaccine (Zhifei Lvzhu)

Development stage
Unknown
Lead developer
Zhifei Biological
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Meningococcal groups A and C and haemophilus b conjugate vaccine (MenAC-Hib) is a trivalent combination conjugate vaccine developed by Beijing Zhifei Lvzhu Biopharmaceutical. It is designed for the active immunization of infants and young children against invasive diseases caused by *Neisseria meningitidis* serogroups A and C and *Haemophilus influenzae* type b (Hib). The vaccine consists of purified capsular polysaccharides from these three pathogens, each individually conjugated to a tetanus toxoid carrier protein. This conjugation converts the polysaccharides from T-cell independent to T-cell dependent antigens, significantly enhancing immunogenicity and inducing immunological memory in infants as young as two months of age. It was the first AC-Hib triple vaccine approved globally and is a key component of pediatric vaccination programs in China.

Brand names
Xifeibei
Other names
MenAC-Hib vaccineAC-Hib vaccineMeningococcal Groups A and C and Haemophilus b Conjugate VaccineMeningococcal Groups A and C and Haemophilus influenzae type b Conjugate Vaccine
02

Targets

Neisseria meningitidis group C capsular polysaccharideNmA CPS (Neisseria meningitidis group A capsular polysaccharide)pMHCII (Carrier protein peptide-Major Histocompatibility Complex class II complex)

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