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meningococcal groups A and C conjugate vaccine
- Development stage
- Unknown
- Lead developer
- Sanofi Pasteur
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Meningococcal groups A and C conjugate vaccine (Sanofi) is a bivalent vaccine developed to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A and C. The vaccine consists of purified capsular polysaccharides from these two serogroups, each covalently conjugated to a carrier protein, typically tetanus toxoid. This conjugation converts the T-cell independent polysaccharide antigens into T-cell dependent antigens, which significantly enhances immunogenicity and induces immunological memory, particularly in infants and young children. It is used in regions where serogroups A and C are prevalent and has been utilized as an active control in clinical trials evaluating broader quadrivalent vaccines like MenQuadfi.
- Other names
- Meningococcal Polysaccharide Group A and C Conjugate Vaccinemeningococcal groups A and C conjugate vaccine-Sanofi-meningococcal infection
02
Targets
Neisseria meningitidis group C capsular polysaccharideNmA CPS (Neisseria meningitidis group A capsular polysaccharide)
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