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Drug intelligence / Profile preview
meningococcal polysaccharide a+c + sodium chloride + typhoid vi polysaccharide
- Development stage
- Unknown
- Lead developer
- Parent
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
The drug 'meningococcal polysaccharide a+c + sodium chloride + typhoid vi polysaccharide' is a combination of two distinct polysaccharide vaccines: a bivalent Meningococcal Polysaccharide (Groups A and C) vaccine and a Typhoid Vi Polysaccharide vaccine (Typhim Vi). Developed by Sanofi Pasteur, this combination was specifically utilized as an active control/comparator arm in Phase 2 clinical trials evaluating the tetravalent dengue vaccine (CYD-TDV) in Vietnam. The use of these vaccines as a control provided a health benefit to the control group (protection against meningococcal disease and typhoid fever) while maintaining the observer-blind nature of the study. The meningococcal component targets the capsular polysaccharides of Neisseria meningitidis serogroups A and C, while the typhoid component targets the Vi capsular polysaccharide of Salmonella typhi. Sodium chloride is included as an excipient for tonicity.
- Other names
- Meningococcal A+C vaccine + Typhim Vi
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideVi antigen (Vi capsular polysaccharide)
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