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Meningococcal polysaccharide A + C + Typhoid Vi polysaccharide vaccine

Development stage
Unknown
Lead developer
Sanofi
Modality
Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This is a combination vaccine containing purified capsular polysaccharides from *Neisseria meningitidis* serogroups A and C (meningococcal A and C) and the Vi capsular polysaccharide from *Salmonella enterica* serovar Typhi (typhoid Vi). The vaccine is designed to provide active immunization against both invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A and C, as well as typhoid fever caused by *Salmonella* Typhi. The mechanism of action involves induction of specific antibodies against the respective bacterial capsular antigens, conferring protection by preventing bacterial invasion and subsequent infection. These vaccines are typically administered intramuscularly, often in regions where both diseases are endemic or for travelers to such areas[2][5]. Sodium chloride serves as an excipient to maintain isotonicity.

02

Targets

Neisseria meningitidis group C capsular polysaccharideNmA CPS (Neisseria meningitidis group A capsular polysaccharide)Vi antigen (Vi capsular polysaccharide)

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