Drug intelligence / Profile preview

meningococcal polysaccharide vaccine (A,C,Y,W-135)

Development stage
Phase 4
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular, Subcutaneous
01

Overview

Meningococcal polysaccharide vaccine (A,C,Y,W-135) is an inactivated vaccine designed to provide active immunization against invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W-135. It consists of purified capsular polysaccharides extracted from these specific serogroups of the bacterium. The vaccine works by stimulating the recipient's immune system to produce antibodies against these polysaccharides, thereby conferring protection. Unlike conjugate vaccines, plain polysaccharide vaccines typically elicit a T-cell independent B-cell immune response, which can result in shorter-lived immunity and may be less immunogenic in very young children. This vaccine does not protect against *Neisseria meningitidis* serogroup B or other bacterial pathogens. It is primarily indicated for the prevention of meningococcal infections, including meningitis and septicemia, especially in high-risk populations and during outbreaks.

Brand names
Menomune A/C/Y/W-135Mencevax ACWY
Other names
Meningococcal Groups A, C, Y, and W-135 VaccineGroup ACYW135 Meningococcal Polysaccharide Vaccine
02

Targets

MenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideGroup Y CPS (Neisseria meningitidis group Y capsular polysaccharide)

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