Drug intelligence / Profile preview

meningococcal vaccine GSK134612 + Cervarix + Boostrix

Development stage
Unknown
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

meningococcal vaccine GSK134612 + Cervarix + Boostrix is a co-administration vaccine regimen developed by GSK, specifically evaluated for use in adolescents and young adults. The regimen consists of three distinct vaccine products: GSK134612 (a pentavalent MenABCWY vaccine candidate), Cervarix (a bivalent HPV vaccine), and Boostrix (a Tdap booster). GSK134612 combines the components of the approved vaccines Bexsero and Menveo to provide broad protection against Neisseria meningitidis serogroups A, B, C, W, and Y. Cervarix targets HPV types 16 and 18, which are responsible for the majority of cervical cancers, using the AS04 adjuvant system. Boostrix provides booster immunization against tetanus, diphtheria, and pertussis. This combination approach aims to improve vaccination compliance by reducing the number of clinical visits required to complete the recommended adolescent immunization schedule.

Other names
MenABCWY + HPV + Tdapmeningococcal group A, B, C, W-135 and Y vaccine + human papillomavirus vaccine + tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine
02

Targets

FHA (Filamentous hemagglutinin)HPV16 (Human papillomavirus type 16)HPV18 L1NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)PRN (Pertactin)TT (Tetanus toxoid)TLR4 (Toll-like receptor 4)PT (Pertussis toxin)NHBA (Neisserial heparin-binding antigen)PorAfHbp (Factor H-binding protein)

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