Drug intelligence / Profile preview

Menoforce

Development stage
Unknown
Lead developer
A. Vogel
Modality
Small Molecules
Administration
Oral
01

Overview

Menoforce is a herbal medicinal product developed by A. Vogel AG, containing a concentrated extract of fresh sage (*Salvia officinalis*) leaves. It is specifically indicated for the relief of excessive sweating (hyperhidrosis) and hot flushes associated with menopause. Unlike traditional hormone replacement therapies, Menoforce is thought to exert its effects by stabilizing the thermoregulatory center in the hypothalamus rather than through direct systemic estrogenic activity. Clinical data, including Phase 4 studies, have demonstrated that a once-daily dose of the 3400 mg equivalent extract significantly reduces the frequency and intensity of vasomotor symptoms in menopausal women. The preparation is standardized to ensure consistent levels of active constituents, such as essential oils and phenolic acids, while maintaining a safety profile suitable for long-term use.

Brand names
MenoforceMeno-ForceA.Vogel Sage Tablets
Other names
Salvia officinalis extractSage leaf extractFresh sage extract
02

Targets

SERT (Sodium-dependent serotonin transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))MOR (Mu opioid receptor)ADRA2A (α2A)GABAA (Gamma-aminobutyric acid receptor)CHRM3 (M3)

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