menogarol

**Menogarol** (also known as menogaril, 7-OMEN, or Tomosar) is a synthetic anthracycline antibiotic and a member of the nogalamycin group, developed as an antineoplastic agent. It is structurally related to doxorubicin but was designed to have a reduced cardiotoxicity profile. Menogarol exhibits cytostatic and antitumor activity, showing a broad spectrum of activity in murine tumor models, including leukemia and melanoma. Unlike doxorubicin, menogarol binds weakly to DNA and has a distinct effect on RNA synthesis and cell cycle phase-specific cytotoxicity. It inhibits nucleic acid synthesis less than traditional anthracyclines, and preclinical studies suggested low mutagenicity in bacterial systems. In animal studies, it is active when administered orally or parenterally. Mechanistically, it acts mainly as a DNA synthesis inhibitor. It underwent clinical evaluation but was not taken forward to approval.

Brand names

Tomosar

Other names

7(R)-O-methylnogarol7-OMEN