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menstrual blood-derived mesenchymal stem cell exosomes
- Development stage
- Unknown
- Lead developer
- Creative Biolabs
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intra-arterial, Intravenous, Intperitoneal
01
Overview
Menstrual blood-derived mesenchymal stem cell exosomes (MenSC-Exos) are extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) isolated from human menstrual blood. These bilipid membrane vesicles, typically 30–100 nm in diameter, act as a cell-free therapeutic modality by delivering a bioactive cargo of proteins, lipids, mRNAs, and microRNAs (miRNAs) to recipient cells. MenSC-Exos have been investigated for their regenerative, anti-fibrotic, and anti-apoptotic properties in various conditions, including liver cirrhosis, premature ovarian insufficiency (POI), and diabetic wound healing. They modulate key signaling pathways such as SMAD3/AKT/MDM2/P53 and promote angiogenesis through the delivery of factors like angiopoietin-2 and angiogenin. Clinical studies have demonstrated their potential to reduce portal vein pressure and improve liver function when administered via hepatic artery infusion.
- Other names
- 宫血间充质干细胞来源外泌体Menstrual blood-derived MSC exosomes
02
Targets
MDM2 (Mouse double minute 2 homolog)AKT (RAC-alpha serine/threonine-protein kinase)ANG (Angiogenin (ribonuclease 5))SMAD3 (SMAD family member 3)TP53 (Cellular Tumor Antigen p53 R175H)ICAM1 (Intercellular Adhesion Molecule 1)ANGPT2 (Angiopoietin-2)
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