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menthol + camphor + capsaicin
- Development stage
- Phase 1
- Lead developer
- Haw Par Corporation
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
A combination topical analgesic for **temporary relief of minor aches and pains in muscles and joints**, typically used in the form of creams, gels, or patches. - **Menthol** acts as a counterirritant, producing a cooling sensation by activating TRPM8 receptors and reducing pain perception. - **Camphor** also acts as a counterirritant, producing both cooling and warming sensations that distract from pain, as well as mild local anesthetic effects via TRPV1 and other channels. - **Capsaicin** (from capsicum) acts via sustained activation and subsequent desensitization of the TRPV1 (vanilloid) receptor, resulting in depletion of substance P, a neuropeptide involved in pain transmission, which leads to reduced pain signal transmission[3][5]. The combination is commonly available over the counter for musculoskeletal pain associated with arthritis, backache, sprains, and strains.
- Brand names
- Tiger Balm Pain Relieving Patch
- Other names
- camphor, capsicum, and menthol topical
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)NaV (Voltage-gated sodium channels)
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