menthone glycerin acetal

Menthone glycerin acetal is a synthetic cooling agent and a derivative of menthone. It is primarily utilized in topical, oral care, and cosmetic formulations to provide a sustained cooling sensation without the strong odor or irritation often associated with menthol. The compound functions as an agonist of the Transient Receptor Potential Melastatin 8 (TRPM8) channel, a cold-sensing receptor located on sensory neurons. In clinical research conducted by GSK, menthone glycerin acetal was incorporated into a prototype skin disinfectant spray intended for superficial wounds to enhance consumer liking and provide a soothing, cooling effect during application.

Brand names

Frescolat MGA

Other names

Menthone glycerol ketalMenthone glycerin ketal1,4-Dioxaspiro[4.5]decane-2-methanol, 9-methyl-6-(1-methylethyl)-