Drug intelligence / Profile preview

mephtazolol

Development stage
Phase 2
Lead developer
Shandong Taitian New Drug Development
Modality
Small Molecules
Administration
Oral
01

Overview

Mephtazolol is a novel small molecule analgesic developed by Shandong Taitian New Drug Development for the management of moderate to severe pain, specifically postoperative pain. Chemically, it is a derivative of meptazinol and is classified as a Class 1.1 new drug in China. Mephtazolol primarily functions as an opioid receptor agonist, likely targeting the mu-opioid receptor to provide analgesic effects. Clinical development has focused on its use as an oral tablet for short-term treatment of moderate pain following orthopedic surgery, where it has been evaluated in Phase II trials (e.g., CTR20150566) against active comparators such as tramadol.

Other names
mephtazolol hydrochloride美他唑醇
02

Targets

MOR (Mu opioid receptor)

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