Drug intelligence / Profile preview

MER683

Development stage
Preclinical
Lead developer
Merida Biosciences
01

Overview

MER683 is a biologic therapeutic candidate being developed by Merida Biosciences for the treatment of primary membranous nephropathy (pMN). It is designed to clear pathogenic autoantibodies that target the phospholipase A2 receptor (PLA2R), which are the primary drivers of glomerular damage in this autoimmune kidney disease. By specifically removing these autoantibodies from the circulation, MER683 aims to halt the progression of podocyte injury and promote renal recovery. The program is currently in the IND-enabling stage of development.

Other names
PLA2R-specific AgFcPLA-2R-specific AgFcPLA 2R-specific AgFcPLA2R-specific antigen-Fc fusion proteinsPLA-2R-specific antigen-Fc fusion proteinsPLA 2R-specific antigen-Fc fusion proteins
02

Targets

PLA2R1 (Phospholipase A2 receptor 1)

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