Drug intelligence / Profile preview

merbromin

Development stage
Unknown
Lead developer
Hynson, Westcott & Dunning
Modality
Small Molecules
Administration
Topical
01

Overview

Merbromin is an organomercuric disodium salt compound used as a topical antiseptic for minor cuts and scrapes and as a biological dye. It is primarily indicated for the treatment and prevention of skin infections from minor wounds, burns, abrasions, diabetic foot ulcers, neuropathic ulcers, and in the antisepsis of the umbilical cord. The drug acts by releasing mercury ions upon application to wounds; these ions have potent antimicrobial properties that interfere with bacterial enzymes by binding to sulfhydryl groups on proteins—denaturing them and inhibiting essential metabolic functions. Merbromin is effective against a broad spectrum of microbes including bacteria (both gram-positive and gram-negative), fungi, viruses, and protozoa. Due to concerns about mercury toxicity it has been withdrawn from markets in several countries including Switzerland, France, Germany, Denmark, Brazil and the United States[1][2][4][5][6].

Brand names
MercurochromeMerbromineMercurocolSodium mercuresceinAsceptichromeSupercromeBrocaseptCinfacromin
Other names
Stellachrome
02

Targets

Mpro (3C-like proteinase of SARS-CoV-2)NEC (Human cytomegalovirus nuclear egress complex)

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