Drug intelligence / Profile preview

meropenem + vancomycin + ceftazidime + ceftriaxone + ceftizoxime + linezolid

Development stage
Unknown
Lead developer
Sumitomo Pharma
Modality
Small Molecules
Administration
Intravenous, Oral, Intramuscular, Intrathecal, Intraventricular
01

Overview

This is a combination of six different antibiotics, each with distinct mechanisms of action and clinical applications. The combination includes: - **Meropenem**: A broad-spectrum carbapenem antibiotic active against Gram-positive and Gram-negative bacteria. It penetrates bacterial cells and interferes with cell wall synthesis. - **Vancomycin**: A glycopeptide antibiotic used to treat severe bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). - **Ceftazidime**: A third-generation cephalosporin with activity against Gram-negative bacteria, including Pseudomonas aeruginosa. - **Ceftriaxone**: A third-generation cephalosporin with broad-spectrum activity. - **Ceftizoxime**: A third-generation cephalosporin antibiotic. - **Linezolid**: An oxazolidinone antibiotic effective against resistant Gram-positive bacteria. This specific combination of six antibiotics is not a standard treatment regimen but represents individual agents that might be used in various combinations for severe, complex, or resistant infections.

02

Targets

D-Ala-D-Ala (D-Ala-D-Ala terminus)β-lactamasePBP (Penicillin-binding protein family)23S rRNA (23S ribosomal RNA)

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