mesalazine + ciprofloxacin

Mesalazine + ciprofloxacin is a combination of two pharmaceutical agents used primarily for their respective actions in inflammatory bowel disease and bacterial infections. Mesalazine (also known as mesalamine or 5-aminosalicylic acid) is an aminosalicylate anti-inflammatory drug that acts mainly topically in the colon to treat mild to moderate ulcerative colitis and maintain remission. Its mechanism involves inhibition of prostaglandin synthesis and leukotriene pathways as well as scavenging free radicals[2]. Ciprofloxacin is a second-generation fluoroquinolone antibiotic effective against a broad range of Gram-negative and some Gram-positive bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV[8]. The combination may be considered in clinical scenarios where patients with inflammatory bowel disease develop concurrent bacterial infections requiring antibiotic therapy. Clinical studies indicate no significant pharmacokinetic interaction between MMX mesalamine formulations and ciprofloxacin; both drugs can be coadministered without affecting efficacy or safety profiles[1][3][4].

Brand names

AsacolMezavantZaldyonCetraxalCiloxanCipro HCCiprodexCiprofloxacin (as a brand)OtiprioOtixalOtovelProquin

Other names

5-aminosalicylic acid + ciprofloxacin