Mesenchymal stem cell-derived exosome

Mesenchymal stem cell-derived exosomes are nano-sized extracellular vesicles (30–150 nm) secreted by mesenchymal stem cells (MSCs) that function as potent mediators of intercellular communication. These vesicles carry a complex cargo of bioactive molecules, including growth factors, cytokines, and microRNAs, which modulate the microenvironment of recipient cells. In the context of dermatology and aesthetic medicine, MSC-derived exosomes are utilized for their regenerative and anti-inflammatory properties. When administered intradermally, they stimulate dermal fibroblasts to enhance the synthesis of structural proteins such as Type I collagen and elastin, while simultaneously inhibiting the expression of matrix metalloproteinases that degrade the extracellular matrix. This specific therapy is currently being evaluated in a Phase 3 clinical trial (NCT05659030) led by investigator Mert Ersan to assess its efficacy in improving facial skin quality and reversing signs of aging, such as wrinkles and loss of elasticity.

Other names

MSC-derived exosomeMSC-ExoMesenchymal stem cell-derived suspended exosome