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mesenchymal stem cell-derived neural progenitor cells
- Development stage
- Phase 2
- Lead developer
- Tisch MS Research Center of New York
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intrathecal
01
Overview
Mesenchymal stem cell-derived neural progenitor cells (MSC-NPs) are a specialized cell therapy derived from autologous bone marrow mesenchymal stem cells (MSCs) that undergo ex vivo manipulation to develop neural characteristics. They represent a neural subpopulation of MSCs characterized by high expression of neural markers including Nestin, downregulation of mesenchymal markers such as smooth muscle α-2 actin and CD90, and reduced multipotency. MSC-NPs retain trophic and immunomodulatory functions associated with increased expression and secretion of growth factors including hepatocyte growth factor (HGF), glial derived neurotrophic factor, insulin-like growth factor, and leukemia inhibitory factor. They are administered intrathecally and are being investigated primarily for the treatment of progressive multiple sclerosis, where they may target both immune and neurodegenerative mechanisms of the disease.
- Brand names
- Tolerostem
- Other names
- MSC-derived neural progenitorsMSC-neural progenitors
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