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Mesenchymal stem cells (University Hospital Tuebingen)
- Development stage
- Unknown
- Lead developer
- University Hospital Tübingen
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intra-portal, Intravenous
01
Overview
This investigational cell therapy involves donor-specific, bone marrow-derived mesenchymal stem cells (MSCs) developed by the University Hospital Tuebingen for use in pediatric living-donor liver transplantation. The MSCs are harvested from the donor's iliac crest approximately four weeks before the transplant and expanded in a GMP-compliant facility using animal-free media. Administered via the intra-portal or intravenous route, the therapy aims to utilize the immunomodulatory properties of MSCs to promote allograft tolerance and reduce the requirement for high-dose calcineurin inhibitor (CNI) immunosuppression. By modulating the recipient's immune response, the treatment seeks to minimize CNI-related toxicities and prevent long-term graft inflammation and fibrosis in pediatric patients.
- Other names
- Donor-specific mesenchymal stem cellsBone marrow-derived mesenchymal stem cellsDonor-derived mesenchymal stem cells
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