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mesenchymal stromal cell-derived extracellular vesicle complex
- Development stage
- Unknown
- Lead developer
- Good Cells
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Vaginal
01
Overview
Mesenchymal stromal cell-derived extracellular vesicle complex is an investigational, allogeneic, cell-free biologic therapy developed by Good Cells LLC. It is designed for the treatment of vulvovaginal atrophy (VVA), specifically targeting symptoms such as vaginal dryness and pain in peri- and postmenopausal women. The therapeutic consists of extracellular vesicles (EVs) harvested from mesenchymal stromal cells (MSCs), which contain a complex cargo of proteins, microRNAs, and mRNAs. These bioactive molecules are intended to modulate inflammatory processes and stimulate tissue repair and regeneration within the vaginal mucosa following a single intramucosal injection.
- Other names
- mesenchymal stromal cell-derived extracellular vesicle complexMSC-derived EV complex
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)STAT3 (Signal Transducer and Activator of Transcription 3)HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))TLR4 (Toll-like receptor 4)
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