mesenchymal stromal cell extracellular vesicles

Mesenchymal stromal cell extracellular vesicles (MSC-EVs) are nano-sized, membrane-bound particles secreted by mesenchymal stromal cells (MSCs) that encapsulate a diverse cargo of proteins, lipids, and nucleic acids (such as microRNAs). They function as critical mediators of intercellular communication, recapitulating many of the therapeutic paracrine effects of their parent cells. MSC-EVs are being developed as a cell-free alternative to MSC therapy, offering potential advantages in terms of safety, reduced immunogenicity, and manufacturing scalability. They exhibit potent immunomodulatory, anti-inflammatory, and regenerative properties, making them candidates for treating a wide range of conditions including inflammatory diseases, autoimmune disorders, and tissue injuries. Current research, such as that conducted by Sartorius, focuses on optimizing scalable downstream processing (DSP) using bioreactors and chromatography to produce high-purity EV products by depleting non-vesicular extracellular particles (NVEPs).

Other names

MSC-EVsmesenchymal stem cell-derived extracellular vesiclesMSC-derived exosomesmesenchymal stromal cell-derived extracellular vesicles