Mesenchymal stromal cells

Mesenchymal stromal cells (MSCs) are multipotent progenitor cells that possess significant immunomodulatory, anti-inflammatory, and regenerative properties. In the context of the clinical program led by Guangdong Provincial People's Hospital, these cells are being evaluated as an adjunctive therapy for newly diagnosed chronic graft-versus-host disease (cGvHD). MSCs function by secreting various soluble factors and through direct cell-to-cell contact to inhibit the proliferation and function of effector T-cells and B-cells, while promoting the induction of regulatory T-cells (Tregs). This modulation helps to suppress the pathological immune response characteristic of cGvHD, potentially improving response rates when added to standard immunosuppressive regimens like corticosteroids and calcineurin inhibitors.

Other names

Mesenchymal stem cellsMSCsMSC