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mesenchymal stromal cells (f21577)
- Development stage
- Unknown
- Lead developer
- University Medical Center Utrecht
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intranasal
01
Overview
Developed by University Medical Center (UMC) Utrecht, this experimental cell therapy consists of allogeneic bone marrow-derived mesenchymal stromal cells (MSCs) for the treatment of perinatal arterial ischemic stroke (PAIS) in neonates. Administered intranasally via nose drops, these "off-the-shelf" cells are manufactured at UMC Utrecht's GMP-accredited Cell Therapy Facility from healthy human donors. The therapy leverages the neuroregenerative and anti-inflammatory properties of MSCs, which secrete growth factors and cytokines to stimulate endogenous brain repair processes and reduce tissue damage following a neonatal stroke. It is currently being evaluated in the Phase 1/2 PASSIoN trial.
- Other names
- mesenchymal stem cellsallogeneic bone marrow-derived mesenchymal stromal cellsintranasal MSCs
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