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MESO-CAR T
- Development stage
- Preclinical
- Lead developer
- Shanghai Cell Therapy Research Institute
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies, Antibody-Based Therapeutics
- Administration
- Intravenous, Intrapleural, Intraperitoneal
01
Overview
MESO-CAR T is a type of Chimeric Antigen Receptor (CAR) T-cell therapy, specifically an autocrine PD-1 nano antibody MesO-CAR T. This therapy involves genetically engineering a patient's own T cells to express a Chimeric Antigen Receptor that targets mesothelin (MSLN), a protein frequently overexpressed on various solid tumor cells. Additionally, these CAR-T cells are designed to produce an autocrine PD-1 nano antibody, which aims to block PD-1 signaling within the CAR-T cells or in the tumor microenvironment. This dual mechanism is intended to enhance the anti-tumor activity of the T cells by overcoming immune suppression and improving their persistence and efficacy against mesothelin-expressing cancers, such as advanced gastric cancer.
- Other names
- 自分泌PD-1纳米抗体meso-CAR-T
02
Targets
Mesothelin
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