mesoporous platinum nanoparticles

Mesoporous platinum nanoparticles are engineered platinum-based nanomaterials characterized by a highly porous structure and large specific surface area. Their mesoporous architecture enables high drug loading, controlled release, and efficient cellular uptake. These nanoparticles are typically synthesized with surfactants, such as Pluronic F127, and may be further functionalized with polymers (e.g., polyethylene glycol) or other bioactive molecules for enhanced biocompatibility and stability. Mechanistically, mesoporous platinum nanoparticles serve as multifunctional nanoplatforms for: - **Chemotherapy**: Acting as carriers for chemotherapeutic drugs (e.g., doxorubicin), facilitating targeted delivery and overcoming drug resistance, with triggered drug release capabilities in response to environmental cues (such as acidic pH)[7][9][11]. - **Photothermal Therapy**: Exhibiting photothermal conversion upon near-infrared laser irradiation, leading to localized heating and cancer cell ablation[7][9][11]. - **Sonodynamic Therapy**: Serving as sonosensitizers, these nanoparticles generate reactive oxygen species (ROS) under ultrasound irradiation, inducing tumor cell death via cavitation and oxidative stress[5]. - **Diagnostic Imaging**: Their high electron density and ability to be loaded with imaging agents enable their use in computed tomography (CT) and MRI imaging, providing theranostic functionality[7][9]. The underlying mechanism of anti-cancer action includes enhanced generation of ROS, promoting oxidative damage and apoptosis in cancer cells. Platinum ions may also interact with DNA to inhibit replication, thereby exerting cytotoxic effects. Mesoporous platinum nanoparticles can be modified for selective targeting to tumors and drug-resistant cells, potentially improving efficacy and reducing systemic toxicity[7][9][10][11].

Other names

MPNPsmesoPtmesoporous PtNPs