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MET-5

Development stage: Phase 1
Lead developer: NuBiyota
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

**MET-5** is an investigational, defined human microbiome therapeutic developed by NuBiyota. It is a multi-strain bacterial consortium composed of 26 bacterial strains isolated from the stool of a healthy donor distinct from the donor used for MET-3. MET-5 is intended to modify or restore gut microbial ecosystem function and was evaluated in a pilot clinical study in adults with hypertriglyceridemia and metabolically benign obesity, with fasting serum triglyceride concentration as a principal metabolic outcome.

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