Drug intelligence / Profile preview

MET-CODCP 19

Development stage: Preclinical
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Oral

Overview

MET-CODCP 19 is a specialized oral nanoplatform consisting of metformin-bridged nanocochleates (MET-CO) optimized with dicetyl phosphate (DCP). This formulation was developed to repurpose metformin hydrochloride for the treatment of hepatocellular carcinoma (HCC), addressing the drug's high aqueous solubility and poor oral permeability. The nanocochleates are structured as uniform, snail-shaped nano-rolls that provide a controlled biphasic release profile over 24 hours. Preclinical studies demonstrate that MET-CODCP 19 significantly enhances the oral bioavailability of metformin (approximately 5.5-fold relative to standard solution) and exhibits potent anticancer activity by downregulating anti-apoptotic and cancer stemness genes in HepG2 cells.

Other names: metformin-bridged nanocochleates

Targets

AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)

Beyond the preview

Go deeper on MET-CODCP 19.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on MET-CODCP 19.

Explore the full profile