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METABO is a multi-ingredient dietary supplement primarily composed of raspberry ketone, caffeine, capsaicin, garlic, ginger, and Citrus aurantium. It has been studied as an adjunct to an eight-week weight loss program, demonstrating safety and efficacy in augmenting improvements in body composition, waist and hip girth. Clinical trials showed significant reductions in body weight, fat mass, and waist and hip girth, along with an increase in lean mass and energy levels, compared to placebo. The supplement also showed effects on maintaining elevated serum leptin and decreasing serum resistin during the initial weeks of the study. Ongoing studies are being conducted to confirm these results and elucidate the underlying biochemical and neuroendocrine mechanisms.
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