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Metabolica engineered live biotherapeutic
- Development stage
- Preclinical
- Lead developer
- Metabolica Health
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Metabolica Health's lead candidate is an engineered live biotherapeutic product (LBP) developed using synthetic biology to modulate the gut microbiome, specifically targeting the 4-cresol metabolic pathway. 4-cresol is a microbial metabolite identified as a potential therapeutic agent for chronic metabolic conditions due to its ability to enhance insulin secretion and promote pancreatic beta-cell proliferation. By engineering commensal bacteria to produce or regulate 4-cresol levels within the gastrointestinal tract, Metabolica aims to restore metabolic homeostasis. The therapeutic is intended for the treatment of chronic metabolic diseases such as type 2 diabetes and obesity and is currently in the preclinical stage of development.
- Other names
- Engineered Live Biotherapeutic Product4-cresol pathway-engineered LBPMetabolica LBP
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