Metabolife Ephedra-Free

Metabolife Ephedra-Free is a multicomponent herbal dietary supplement marketed as an aid for weight loss. It was developed as a reformulation of the original Metabolife 356, which contained ephedra (ephedrine), after ephedra was banned in the United States due to safety concerns. The "Ephedra-Free" version does not contain ephedrine but instead includes other herbal stimulants and ingredients commonly found in weight-loss supplements, such as guarana (a source of caffeine) and possibly bitter orange extract (Citrus aurantium), which contains synephrine—a compound with stimulant properties similar to those of ephedrine. The exact ingredient list may vary by batch or manufacturer, but these are typical components. Mechanistically, the supplement acts primarily through central nervous system stimulation via caffeine and/or synephrine, increasing metabolic rate and potentially promoting weight loss. However, clinical studies have shown that while single doses do not significantly affect blood pressure in healthy young adults, there can be increases in systemic vascular resistance index (SVRI). Prolonged use or use among individuals with pre-existing cardiovascular conditions may pose health risks similar to those seen with earlier ephedra-containing products[3][5][7].

Brand names

Metabolife Ephedra-Free

Other names

Metabolife Ephedra-Free