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**Metaderm** is a nonprescription topical homeopathic botanical cream marketed for temporary relief of psoriasis-associated dryness, itching, flaking, rash, redness, and skin irritation. The U.S. DailyMed label identifies eight homeopathic active botanical ingredients and states that the product has not been evaluated by the FDA for safety or efficacy. Metaderm cream was evaluated in an investigator-initiated, open-label University of Alabama at Birmingham study in plaque psoriasis, registered as NCT03597620. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=737b1c88-1a43-68cf-e053-2991aa0a35b6))
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