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metafenine
- Development stage
- Unknown
- Lead developer
- Guangzhou Nanxin Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Metafenine is an orally bioavailable small molecule multi-kinase inhibitor developed by Guangzhou Nanxin Pharmaceutical. It is designed to target several receptor tyrosine kinases (RTKs) that play critical roles in tumor angiogenesis and cell proliferation, specifically the Vascular Endothelial Growth Factor Receptors (VEGFR), Fibroblast Growth Factor Receptors (FGFR), and Platelet-Derived Growth Factor Receptors (PDGFR). By inhibiting these pathways, metafenine aims to disrupt the tumor's blood supply and inhibit the growth of cancer cells. The drug is currently being evaluated in Phase Ib/IIa clinical trials in China for the treatment of advanced primary liver cancer (hepatocellular carcinoma), particularly in patients who have failed or are ineligible for standard systemic or local antitumor therapies.
- Other names
- 美他非尼
02
Targets
FGFR (Fibroblast growth factor receptor)PDGFR (PDGFR family)VEGFR (VEGFR family)
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