Drug intelligence / Profile preview

MetControl

Development stage
Discontinued
Lead developer
Generex Biotechnology
Modality
Small Molecules
Administration
Buccal, Oral
01

Overview

MetControl (Generex Metformin Gum) is a medicinal chewing gum formulation of the biguanide **metformin**, developed by **Generex Biotechnology** in collaboration with **Fertin Pharma**. Designed for the treatment of type 2 diabetes mellitus and obesity, the product utilizes a buccal drug delivery system to provide systemic absorption of metformin through the oral mucosa. This delivery method is intended to bypass the gastrointestinal tract, thereby mitigating the common adverse GI side effects—such as nausea, vomiting, and diarrhea—that often limit the tolerability of traditional metformin tablets. Each piece of gum contains 214.5 mg of metformin. The product was originally positioned as a companion therapy to Generex's oral insulin spray, Oral-lyn, to improve patient compliance and glycemic control.

Brand names
MetControl
Other names
Generex Metformin Gum
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)GPD2 (Glycerol-3-phosphate dehydrogenase 2)

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