Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
metformin + esomeprazole
- Development stage
- Phase 4
- Lead developer
- ChristianaCare
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Metformin + Esomeprazole is a combination therapy being investigated by Christiana Care Health Services for the treatment of preterm preeclampsia. Metformin, a biguanide typically used for type 2 diabetes, and esomeprazole, a proton pump inhibitor, are hypothesized to work additively to reduce the secretion of antiangiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng). These factors are key drivers of endothelial dysfunction and the clinical manifestations of preeclampsia. By lowering these harmful serum markers, the treatment aims to prolong pregnancy and improve maternal and fetal outcomes in women undergoing expectant management for preterm preeclampsia between 24 and 32 weeks of gestation. The combination is currently being evaluated in a Phase 4 clinical trial.
- Other names
- Metformin and Esomeprazole combination
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ATP4A (Potassium–transporting ATPase alpha chain 1)ND1 (Mitochondrial electron transport chain complex I)ENG (Integrin Beta 6)sFlt-1 (Soluble VEGFR-1)
Beyond the preview
Go deeper on metformin + esomeprazole.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on metformin + esomeprazole.