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metformin + entecavir

Development stage: Discontinued
Lead developer: Bristol Myers Squibb
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy approach involving metformin as an add-on to entecavir treatment for chronic hepatitis B (CHB) infection. This combination was studied to potentially accelerate hepatitis B surface antigen (HBsAg) clearance, which would indicate functional cure of CHB. Metformin was hypothesized to have antiviral and immunomodulatory effects that could complement entecavir's action. However, clinical trials showed that while safe, metformin add-on therapy did not significantly accelerate HBsAg clearance compared to entecavir alone.

Other names: Metformin Add-on to EntecavirMetformin and Entecavir Combination

Targets

AMPK (Adenosine monophosphate–activated protein kinase)OCT2 (Organic cation transporter 2)HBV Pol (Hepatitis B virus polymerase)SLC28A3 (Solute carrier family 28 member 3)CNT2 (Concentrative nucleoside transporter 2)OAT1 (Organic anion transporter 1)

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