metformin + insulin

Metformin + insulin is a combination therapy used primarily for the management of type 2 diabetes mellitus. Metformin, a biguanide antihyperglycemic agent, works by decreasing hepatic glucose production (gluconeogenesis), reducing intestinal absorption of glucose, and increasing peripheral insulin sensitivity. Insulin is an endogenous hormone or exogenous biologic that facilitates cellular uptake of glucose and regulates blood sugar levels. When used together, this combination improves glycemic control more effectively than either agent alone, reduces required doses of insulin, and may limit weight gain associated with intensive insulin therapy. This regimen is indicated when monotherapy does not achieve adequate glycemic control in patients with type 2 diabetes[1][2][4][5].

Brand names

Humulin Mixtard

Other names

Metformin and Insulin