Drug intelligence / Profile preview

metformin + Scutellaria baicalensis extract

Development stage
Unknown
Lead developer
Namyi Gu
Modality
Small Molecules
Administration
Oral
01

Overview

This is an investigational combination therapy comprising the biguanide antidiabetic agent metformin and an extract from the root of *Scutellaria baicalensis*, a traditional medicinal herb. Developed by researchers led by Dr. Namyi Gu at Dongguk University, the therapy is intended for the treatment of type 2 diabetes mellitus. The *S. baicalensis* extract contains bioactive flavonoids such as baicalin and wogonoside. Clinical studies suggest that the combination works synergistically to improve glucose tolerance and lipid profiles while reducing systemic inflammation. A key proposed mechanism involves the modulation of the gut microbiota, specifically increasing the abundance of beneficial bacteria like *Lactobacillus* and *Akkermansia*.

Other names
metformin + S. Baicalensismetformin + Scutellaria baicalensisMetformin and S. Baicalensis Combination Therapy
02

Targets

SLC47A1 (Multidrug and toxin extrusion transporter 1)AMPK (Adenosine monophosphate–activated protein kinase)

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