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metformin + ursodeoxycholic acid
- Development stage
- Phase 3
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination drug consisting of metformin and ursodeoxycholic acid (UDCA). Metformin is an antidiabetic medication that improves insulin sensitivity and reduces hepatic glucose production, while UDCA is a hydrophilic bile acid with protective effects on the liver. This combination is being studied for treating non-alcoholic steatohepatitis (NASH) and potentially beneficial for patients with type 2 diabetes mellitus (T2DM) due to its complementary effects on insulin resistance, oxidative stress, and liver protection.
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ABCB11 (Bile salt export pump)FXR (Farnesoid x-activated receptor)GR (Glucocorticoid receptor)INSR (Insulin receptor)ND1 (Mitochondrial electron transport chain complex I)ABCC2 (ATP-binding cassette sub-family C member 2)PXR (Pregnane X receptor)BAR (Bile acid receptor)
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