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methadone + ketamine
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination of methadone, a synthetic opioid that acts primarily as a full μ-opioid receptor agonist, but uniquely also functions as an NMDA receptor antagonist[3][7] and inhibits serotonin and norepinephrine uptake[3], and ketamine, a noncompetitive NMDA receptor antagonist[1]. This combination has been studied for management of post-surgical pain, neuropathic pain, and as part of fast-track cardiac anesthesia protocols.
- Other names
- ketamine and methadonemethadone plus ketamineketamine/methadone combination
02
Targets
KOR (Kappa opioid receptor)MOR (Mu opioid receptor)NMDAR (Glutamate receptor ionotropic, NMDA)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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